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Apr 29 - Scientists on brink of HIV cure


 Apr 29 - Scientists on brink of HIV cure
topic by PRiNC3SSxKiSS - 04-29-2013, 12:23 PM - Boxden > BX Daily Bugle - news and headlines


Researchers believe that there will be a breakthrough in finding a cure for HIV “within months”.

Danish scientists are expecting results that will show that “finding a mass-distributable and affordable cure to HIV is possible”.
They are conducting clinical trials to test a “novel strategy” in which the HIV virus is stripped from human DNA and destroyed permanently by the immune system.
The move would represent a dramatic step forward in the attempt to find a cure for the virus, which causes Aids.
The scientists are currently conducting human trials on their treatment, in the hope of proving that it is effective. It has already been found to work in laboratory tests.
The technique involves releasing the HIV virus from “reservoirs” it forms inside DNA, bringing it to the surface of the cells. Once it comes to the surface, the body’s natural immune system can k!ll the virus through being boosted by a “vaccine”.

In vitro studies — those that use human cells in a laboratory — of the new technique proved so successful that in January, the Danish Research Council awarded the team 12 million Danish kroner (£1.5 million) to pursue their findings in clinical trials with human subjects.
These are now under way, and according to Dr Ole Søgaard, a senior researcher at the Aarhus University Hospital in Denmark and part of the research team, the early signs are “promising”.
“I am almost certain that we will be successful in releasing the reservoirs of HIV," he said.
“The challenge will be getting the patients’ immune system to recognise the virus and destroy it. This depends on the strength and sensitivity of individual immune systems.”
Fifteen patients are currently taking part in the trials, and if any of them are found to have successfully been cured of HIV, the “cure” will be tested on a wider scale, aided by an immune system booster.
Dr Søgaard stressed that a cure is not the same as a preventative vaccine, and that raising awareness of unsafe behaviour, including unprotected s3x and sharing needles, remains of paramount importance in combating HIV.
With modern HIV treatment, a patient can live an almost normal life, even into old age, with limited side effects.
However, if medication is stopped, HIV reservoirs become active and start to produce more of the virus, meaning that symptoms can reappear within two weeks.
Finding a cure would free a patient from the need to take continuous HIV medication, and save health services billions of pounds.
The technique is being researched in Britain, but studies have not yet moved on to the clinical trial stage. Five universities — Oxford, Cambridge, Imperial College, London, University College, London and King’s College, London — have jointly formed the Collaborative HIV Eradication of Reservoirs UK Biomedical Research Centre group (CHERUB), which is dedicated to finding an HIV cure.
They have applied to the Medical Research Council for funding to conduct clinical trials, which will seek to combine techniques to release the reservoirs of HIV with immunotherapy to destroy the virus.
In addition, they are focusing on patients that have only recently been infected, as they believe this will improve chances of a cure. The group hopes to receive a funding decision in May.
“When the first patient is cured in this way it will be a spectacular moment,” says Dr John Frater, a clinical research fellow at the Nuffield School of Medicine, Oxford University, and a member of the CHERUB group.
“It will prove that we are heading in the right direction and demonstrate that a cure is possible. But I think it will be five years before we see a cure that can be offered on a large scale.”
The Danish team’s research is among the most advanced and fast moving in the world, as that they have streamlined the process of putting the latest basic science discoveries into clinical testing.
This means that researchers can progress more quickly to clinical trials, accelerating the process and reaching reliable results sooner than many others.
The technique uses drugs called HDAC Inhibitors, which are more commonly used in treating cancer, to drive out the HIV from a patient’s DNA. The Danish researchers are using a particularly powerful type of HDAC inhibitor called Panobinostat.
Five years ago, the general consensus was that HIV could not be cured. But then Timothy Ray Brown, an HIV sufferer — who has become known in the field as the Berlin Patient — developed leukaemia.
He had a bone marrow transplant from a donor with a rare genetic mutation that made his cells resistant to HIV. As a result, in 2007 Mr Brown became the first man to ever be fully cured of the disease.
Replicating this procedure on a mass scale is impossible. Nevertheless, the Brown case caused a sea change in research, with scientists focusing on finding a cure as well as suppressing the symptoms.
Two principal approaches are currently being pursued. The first, gene therapy, aims to make a patient’s immune system resistant to HIV. This is complex and expensive, and not easily transferrable to diverse gene pools around the world.
The second approach is the one being pursued by Dr Søgaard and his colleagues in Denmark, the CHERUB group in Britain, and by other laboratories in the United States and Europe.
Source


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26 comments for "Apr 29 - Scientists on brink of HIV cure"


 04-29-2013, 12:26 PMaway - #2
matelyan 17 heat pts17

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Finally!!! Now we will ALL have access to whatever Magic Johnson has been taking these past 20 years!
 04-29-2013, 12:41 PMaway - #3
Tha Problum 34 heat pts34

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we hear this every year. nothings gonna change. someone always comes up with a cure or say they're close and then we don't hear any follow ups or they disappear. literally every year.
 04-29-2013, 12:44 PMaway - #4
Spiffy 34 heat pts34

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america is like "lol we'll see about that"
 04-29-2013, 12:54 PMaway - #5
WestbankThugBoy 13 heat pts13

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Originally Posted by Spiffy
the government is like "lol we'll see about that"
Fixed
 04-29-2013, 01:18 PMaway - #6
360crazy 7 heat pts

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Damn God should of been gave us a cure for that bull#### a$s disease he created....

But back to reality.... finally
 04-29-2013, 02:00 PMaway - #7
Alerts 146 heat pts146

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Thank means someone is going to create another disease thats worse, Companies that cure diseases don't make profits over time
 04-29-2013, 02:01 PMaway - #8
Shyne-C 72 heat pts72

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Did ya'll hear? Michael jordan is retiring from basketball to play baseball!.. #### is crazy
 04-29-2013, 02:40 PMaway - #9
davilla24c 5 heat pts

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The cure was made the same day they created it doe
 04-29-2013, 03:08 PMonline - #10
420Sosa 1 heat pts

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Originally Posted by 360crazy
Damn God should of been gave us a cure for that bull#### a$s disease he created....

But back to reality.... finally
My guy you do know HIV is not a natural disease that humans came with dat #### was created (by da gov't) just like cancer is a funded disease (by da gov't)...

But we've always had the cure, folks jus gotta learn what it is (it's in nature)...
 04-29-2013, 05:36 PMaway - #11
Spiffy 34 heat pts34

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Originally Posted by 360crazy
Damn God should of been gave us a cure for that bull#### a$s disease he created....

But back to reality.... finally
HIV is man made, they did it for the blacks and gays
 04-29-2013, 05:50 PMonline - #12
THERETURNOFK2Z 2 heat pts

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this is definetly different from any other "cure" claim, lets hope it works for the sake of millions!
 04-29-2013, 06:15 PMonline - #13
Yung Dilla 1200 heat pts1200

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Oh great another cure we won't hear about ever again after today.
 04-29-2013, 06:17 PMaway - #14
RubbahBandMayn 

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Every year it's the same story
 04-30-2013, 02:15 AMaway - #15
Bullet22 48 heat pts48

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Originally Posted by 360crazy
Damn God should of been gave us a cure for that bull#### a$s disease he created....

But back to reality.... finally
idk why he even created those diseases in the first place
 04-30-2013, 06:36 AMaway - #16
Trilluminati GA 338 heat pts338

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on the brink?

they been had that ####.
 04-30-2013, 06:59 AMaway - #17
Joehook 3 heat pts

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Originally Posted by Neo22
idk why he even created those diseases in the first place
Cuz "GOD" hates you and loves to watch you suffer.
 04-30-2013, 09:11 AMaway - #18
JudasHatesJesus 91 heat pts91

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welp, i guess i can start raw doggin it
 04-30-2013, 01:37 PMaway - #19
DatDude504 3 heat pts

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I remember reading this #### in the source back in 03

It only worked on black and asian people so they didn't mass produce it
 04-30-2013, 01:43 PMaway - #20
messy marv stan 1351 heat pts1351

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people who come up with cures to diseases are "conviently" made to dissapear
the goverment will claim that the de@ths of scientists are natural or a $uicide
 
 


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